GnRH Agonists- also known as PUBERTY BLOCKERS
GnRH agonists are a class of drugs that inhibit the action of sex hormones including estrogen, progesterone, and testosterone. This class of drug has been around for nearly fifty years and is used in a variety of situations including some types of cancer, endometriosis, uterine fibroids, and for children undergoing puberty at a young age.
In trans and gender diverse youth, this drug is used to pause puberty. This prevents the natal development of secondary sex characteristics during the process of puberty, preserving choice for the youth and preventing the potential distress caused by undergoing a puberty that does not match their gender identity.
Unlike natal puberty, the effects of puberty blockers are completely reversible upon discontinuation of the drug. Unless other medical interventions are made, natal puberty will progress once treatment with GnRH agonists are discontinued, including fertility.
The decision to use puberty blockers is not something that is taken lightly. It is a joint decision between the patient, their caregivers, and a physician. Youth who hope to begin using puberty blockers are required to undergo lab tests including blood tests, ECG, and bone mineral density testing. Regular monitoring is also a requirement.
When used appropriately and monitored, GnRH Agonists are safe, effective, and life saving drugs.
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